Plasma, urine and skin pharmacokinetics of cefepime in burns patients.

نویسندگان

  • E Sampol
  • A Jacquet
  • M Viggiano
  • V Bernini
  • J C Manelli
  • B Lacarelle
  • A Durand
چکیده

We studied the pharmacokinetics of cefepime (2 g bd) in six burns patients. Blood, urine and skin samples were collected to measure cefepime concentrations. A two-compartment model was fitted to the data. At day 1, t(1/2beta) was 2.45 +/- 0.56 h, V(ss) 0.36 +/- 0.1 L/kg, total clearance 152 +/- 25.2 mL/min, and AUC 217 +/- 34 mg*h/L. There was no statistical difference between day 1 and day 3 for any of the pharmacokinetic parameters. We demonstrated good penetration of cefepime in skin. These results show that it is not necessary to change the standard dosage of cefepime in burns patients.

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عنوان ژورنال:
  • The Journal of antimicrobial chemotherapy

دوره 46 2  شماره 

صفحات  -

تاریخ انتشار 2000